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REDUCED PLASMA ANTIOXIDANT LEVELS IN SMOKING ASTHMATICS

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Author(s): Rajalakshmi G | Sudha S

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 3;
Issue: 1;
Start page: 142;
Date: 2012;
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Keywords: Oxidative stress | Bronchial asthma | Thiobarbituric reactive substances | Total reduced glutathione.

ABSTRACT
The imbalance in antioxidants is thought to play an important role in the pathogenesis of bronchial asthma. The present study was undertaken to evaluate the status of lipid peroxidation and antioxidants as biomarkers in human plasma. The extent of lipid peroxidation as evidenced by the formation of thiobarbituric acid reactive substances (TBARS) and the status of the antioxidants by reduced glutathione (GSH) in the smokers with and without asthma. The mean TBARS levels were higher among smokers with asthma (2.97±1.09) when compared with control smokers (0.75 ±0.81). The mean GSH level were higher in control non-smokers (0.172±0.21) compared to asthma smokers (0.032±0.03) and non smokers (0.061±0.06). Measured parameters confirm that cigarette smoke mediated oxidative stress could represent the primary causative factor in the pathogenesis of asthma.
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