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REGγ Mediated Regulation of p21Waf/Cip1, p16INK4a and p14ARF/p19ARF in Vivo

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Author(s): Lei Li | Pei Zhang | Haibin Wei | Weicang Wang | Liangfang Yao | Yubing Li | Lei Zhou | Zhuo Wang | Jiang Liu | Li Zhou | Ali Amjad | Bianhong Zhang | Tiantian Jing | Jianru Xiao | Yongyan Dang | Xiaotao Li

Journal: Journal of Cancer Therapy
ISSN 2151-1934

Volume: 04;
Issue: 05;
Start page: 933;
Date: 2013;
Original page

Keywords: REGγ | p21Waf/Cip1 | p16INK4a | p14ARF | p19ARF | Cancer

ABSTRACT
p21Waf/Cip1, p16INK4a and p14ARF (p19ARF in mice) have been demonstrated to be degraded by REGγ-proteasome pathway in an ATP- and ubiquitin-independent manner in vitro. However, the in vivo roles of REGγ mediated-degradation of p21Waf/Cip1, p16INK4a and p14ARF remain unclear. In this study, we showed enhanced expression of p21Waf/Cip1, p16INK4a and p19ARF in multiple tissues from REGg–/– mice compared to REGg+/+ mice. Furthermore, we examined the expression of p21Waf/Cip1, p16INK4a and p14ARF in different cancer tissues and observed that the REGγ protein levels were highly expressed in different human cancers while the level of p21Waf/Cip1, p16INK4a and p14ARF appears to be inversely correlated. These results demonstrate that REGγ may exert its function in physiological and pathological conditions through degradation of p21Waf/Cip1, p16INK4a and p14ARF in vivo.

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