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Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata

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Author(s): Chia-Chun Yu | Ching-Ruey Hsieh | George Hsiao | Pi-Yu Chen | Meng-Lun Chang | Hwa-Wen Yin | Tzong-Huei Lee | Ching-Kuo Lee

Journal: Molecules
ISSN 1420-3049

Volume: 17;
Issue: 2;
Start page: 2082;
Date: 2012;
Original page

Keywords: Euphorbia formosana | abietane diterpene | MMP-2 | -9 | HT-1080

ABSTRACT
Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3b,7b-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5b,8a,9b,10a,12a)-12-hydroxyatis-16-ene-3,14-dione (6). The structures of compounds 1−6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3−5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.
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