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Regulation of the actin cytoskeleton in Helicobacter pylori-induced migration and invasive growth of gastric epithelial cells

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Author(s): Wessler Silja | Gimona Mario | Rieder Gabriele

Journal: Cell Communication and Signaling
ISSN 1478-811X

Volume: 9;
Issue: 1;
Start page: 27;
Date: 2011;
Original page

Keywords: Helicobacter pylori | type IV secretion system | CagA | actin cytoskeleton

ABSTRACT
Abstract Dynamic rearrangement of the actin cytoskeleton is a significant hallmark of Helicobacter pylori (H. pylori) infected gastric epithelial cells leading to cell migration and invasive growth. Considering the cellular mechanisms, the type IV secretion system (T4SS) and the effector protein cytotoxin-associated gene A (CagA) of H. pylori are well-studied initiators of distinct signal transduction pathways in host cells targeting kinases, adaptor proteins, GTPases, actin binding and other proteins involved in the regulation of the actin lattice. In this review, we summarize recent findings of how H. pylori functionally interacts with the complex signaling network that controls the actin cytoskeleton of motile and invasive gastric epithelial cells.

Tango Jona
Tangokurs Rapperswil-Jona

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