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The Relation Between IGF-1, GH, IGFBP3 Levels and Stroke and Comorbid Disease

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Author(s): Emine AKINCI | Dilber ÜÇÖZ KOCAŞABAN | Hüseyin Cahit HALHALLI

Journal: Turkish Journal of Emergency Medicine
ISSN 1304-7361

Volume: 12;
Issue: 1;
Start page: 3;
Date: 2012;
Original page

Keywords: Growth hormone | stroke | insulin-like growth factor-1 | insulin-like growth factor binding protein-3.

ABSTRACT
Objectives: The GH/IGF axis (GH: growth hormone; IGF: insulin-like growth factor) includes IGF-1 and -2, specific receptors, and at least six insulin-like growth factor binding proteins (IGFBP). Human and animal studies have shown that the IGF axis, particularly IGF-1, is related to stroke risk. In the present study, we aimed to determine the relationship between IGF-1, GH, IGFBP3, and stroke and comorbid diseases. Methods: This prospective study was conducted between August 2010 and December 2010 at the Emergency Department of Ankara Training and Research Hospital after approval by the local ethics committee. Patients diagnosed with ischemic stroke within 24 hours of symptom onset were included in the study. Gender, age, waist circumference, diabetes mellitus, hypertension, history of stroke, systolic and diastolic blood pressure, lipid profile, and GH, IGF-1, and IGFBP-3 levels were recorded. Results: Fifty patients with ischemic stroke and 30 control patients were included. GH levels were significantly higher in stroke patients than in the control group (0.57 versus 0.06, respectively; p
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