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The Relationship between Changes in Weight Status and Insulin Resistance in Youth

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Author(s): Ondrak KristinS | McMurray RobertG | Battaglini ClaudioL | Evenson Kelly | Harrell JoanneS

Journal: International Journal of Pediatric Endocrinology
ISSN 1687-9848

Volume: 2009;
Issue: 1;
Start page: 862061;
Date: 2009;
Original page

ABSTRACT
This study examined changes in insulin resistance (IR) in 120 youth over two years. IR was quantified via homeostatic model (HOMA-IR), and weight status changes were quantified via body mass index (BMI). When all participants were considered, the mean HOMA-IR and BMI increased 13.4% and 1.65 units, respectively. Change in BMI z-score and percent change in HOMA-IR were moderately associated (). Follow-up analyses were performed for the following weight groups: NN (normal at baseline and two years later), NO (normal to overweight), ON (overweight to normal), and OO (overweight at both points). The NO group had a greater change in HOMA-IR (+50%) compared to other groups: ON (8%), NN (+2%), and OO (0.1%) (). The association between changes in BMI z-score and HOMA-IR was when only the NO and ON groups were included. These results reinforce the importance of preventing youth from becoming overweight to control IR.
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