Academic Journals Database
Disseminating quality controlled scientific knowledge

The relationship between choline plus creatine- to-citrate ratio in magnetic resonance spectroscopy with the invasion of prostate cancer

ADD TO MY LIST
 
Author(s): Ghafoori M | Rasteh M

Journal: Tehran University Medical Journal
ISSN 1683-1764

Volume: 70;
Issue: 9;
Start page: 571;
Date: 2012;
Original page

Keywords: choline | citrate | creatine | magnetic resonance spectroscopy (MRS) | prostate cancer

ABSTRACT
Background: Prostate cancer is the most common cancer and the second cause of cancer mortality in men. Although histopathological examination is the gold-standard for its diagnosis, tendency toward less invasive methods is growing. The purpose of this study was to evaluate the relationship between choline plus creatine- to-citrate ratio in magnetic resonance spectroscopy (MRS) with the invasion of prostate cancer in a series of patients with prostate cancer.Methods: Totally, 200 patients with pathologically proven prostate cancer were enrolled in this cross-sectional study by a non-probability sampling method in Hazrat Rasul Akram Hospital in Tehran, Iran during 2009-2010. Pathological staging was the gold standard for the diagnosis of prostate cancer while the patients underwent MRS for choline plus creatine- to-citrate ratio determination. MRS and pathological results were compared and analyzed.Results: The mean (±SD) values of choline plus creatine- to-citrate ratio in patients with Gleason scores less than 3, 3 to 4 and greater than 4 were 245.8±146.8, 427.1±173.6 and 427.1±173.6, respectively (P
Affiliate Program      Why do you need a reservation system?