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Relationship between Expression of β-tubulin-Ⅲ Plus Stathmin in Advanced Non-Small Cell Lung Cancer and its Sensitivity to Venorelbine Chemotherapy

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Author(s): Xiaolin PU | Jun WANG | Lin XU | Junqing MA | Zhilu WANG | Fuyin LIU | Min YANG | Weifei FAN | Lijuan MENG

Journal: Chinese Journal of Lung Cancer
ISSN 1009-3419

Volume: 12;
Issue: 1;
Start page: 49;
Date: 2009;
Original page

Keywords: Lung neoplasms | Chemotherapy | β-tubulin-Ⅲ | Stathmin

ABSTRACT
Background and objective Vinorelbine plus cisplatin/carboplatin (NP) is one of the standard combination chemotherapy regimen for advanced non-small cell lung cancer (NSCLC). The aim of this study is toinvestigate the relationship between expression of Stathmin and β-tubulin-Ⅲ in NSCLC biopsies and sensitivity to Vinorelbine, which would provide a basis of the proper medicine choice for the patients' tailored chemotherapy. Methods Western blot was used to investigate the expression of Stathmin and β-tubulin-Ⅲ protein in the biopsies from stage ⅢB-Ⅳ NSCLC patients. All the cases were divided into 4 groups according to the level of the two proteins, of which L represented both protein expressed lowly, B showed β-tubulin-Ⅲ lowly expressed group, while S showed Stathmin lowly, and H represented both protein highly expressed. At the same time, all the patients accepted NP chemotherapy for 2 or 4 cycles according to the responses to this regimen. The responses rate (RR), media survival time (MST), time to progress (TTP) were observed. Results A total of 90 stage ⅢB-Ⅳ NSCLC patients were divided into 4 groups, 22 in L group, 23 in B and S group while 22 in H group respectively. The RR of the groups were 68.2%, 26.1%, 30.4% and 22.7% respectively.There were statistically significant differences between L group and other 3 groups (P
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