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The relationship between the frequency of cervical metastases and tumor related factors in laryngeal cancer and outcome of surgical treatment in these cases

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Author(s): Engin Şengül | Tekin Bağlam | Cengiz Çevik | Cemile Arıkan Şengül | Ferit Kara | Zeynel A. Karataş | Muzaffer Kanlıkama

Journal: Journal of Clinical and Experimental Investigations
ISSN 1309-8578

Volume: 3;
Issue: 2;
Start page: 214;
Date: 2012;
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Keywords: Larynx cancer | localization | stage | cervical lymph node metastases | survival

ABSTRACT
Objectives: We aimed to assess the associations betweenlocalization, size, stage and histopathological differentiationof primary tumor in larynx and neck metastases and the impactof disease stage on survival.Materials and methods: We analyzed the medical recordsof 333 laryngeal cancer patients who underwent total or partiallaryngectomy as primary treatment, combined with neckdissection and/or postoperative radiotheraphy if required,between 2000 and 2010 years at our clinic. Age and genderof patients, tumor localization, size, stage and histopathologicaldifferentiation of tumor; presence of preoperative positivelymph nodes, performed operations, operation findingsand histopathological results were analysed retrospectively.Results: Tumor localizations were glottic in 172 (51.6%)cases, supraglottic in 108 (32.4%), and transglottic 53(15.9%) of the the cases. In glottic cancers; cervical metastaseswere observed in 18.6% of the patients, whereasoccult metastases in 11%. In supraglottic cancers; cervicalmetastasis rate was 45.3% and occult metastases rate was24%. In transglottic cancers, cervical metastases rate was49% and occult metastases was 22.6%. Postoperative recurrencewas 41 (12.3%). Postoperative radiotherapy wasrecommended to 111 of 333 patients. The overall survivalrate was 75.4% at 50th month and the cumulative survivalrate was 68.9%.Conclusion: In conclusion, although there is controversyregarding the optimal treatment in the N0 larynx cancers, incase of a high risk for occult metastases, elective unilateralor bilateral neck dissection should be performed accordingto the anatomic localization of the tumor. In addition, survivalrate decreased significantly with the increasing tumor stage.J Clin Exp Invest 2012; 3(2): 214-222
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