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Relationship Between Obesity and 8-hydroxy-2-deoxy Guanosine as an Oxidative Marker in Obese Adolescents of Giza

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Author(s): Amany Elwakkad | Nayera Elmorsi Hassan | Hiba Sibaii | Salwa el Zayat | Lobna Sherif | Enas-R-Abdel Hameed | Azza-Abdel Shaheed

Journal: Journal of Medical Sciences
ISSN 1682-4474

Volume: 11;
Issue: 5;
Start page: 231;
Date: 2011;
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Keywords: oxidative stress | body mass index | Obesity | hydroxyl-guanosine | glutathione

ABSTRACT
This study was conducted to assess the relationship between obesity markers (Body mass index (BMI), fat percentage) and DNA oxidation marker 8-hydroxy-guanosine (OHG) , as a predictor for future clinical problems in obese adolescents of Giza. The study was conducted on 103 adolescents aged 13-18 years (22 boy, 81 girl). BMI was calculated as body weight (kg) divided by height (m2) squared and obesity was defined as BMI of 95 percentile. Fat percentage was determined by using Biological impedance technique. Oxidative stress markers as 8- hydroxyl guanosine, superoxide and glutathione were measured. The adolescents were divided according to BMI into two groups. Group I with BMI >95 percentile and less than 97 percentile (obese) and Group II with BMI >97 percentile (severely obese). Significant differences were detected between the two groups (Group I and II) of the study as regard obesity markers (BMI, fat%) and oxidative stress markers (lipid oxidation, superoxide dismutase enzyme activity, glutathione peroxidase enzyme activity, 8-hydroxyl guanosine) (p
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