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Relationship Between Prohepcidin and Cardiovascular Risk Markers in End Stage Renal Failure Patients

Author(s): Mahmut ARABUL | Serdar KAHVECİOĞLU | Mehmet Ali EREN | Yasemin Üst ÜNDAĞ | Emre SARANDOL | Aysel KADERLİ | Türker EMRE | İbrahim DOĞAN | Mustafa GÜLLÜLÜ

Journal: The Turkish Nephrology, Dialysis and Transplantation Journal
ISSN 1300-7718

Volume: 22;
Issue: 3;
Start page: 290;
Date: 2013;
Original page

Keywords: Cardiovascular risk | Hemodialysis | Peritoneal dialysis | Prohepcidin

OBJECTIVE: The leading cause of death in patients with end-stage renal disease (ESRD) is cardiovascular disease. Prohepcidin, which is the precursor of hepcidin is a peptide hormone produced by the liver, and appears to be the master regulator of iron homeostasis in humans. High prohepcidin levels may contribute to progression of cardiovascular disease in end-stage renal insufficiency patients. However, any such association remains poorly understood. The purpose of the present study was to investigate the relationship between prohepcidin and cardiovascular risk markers in end-stage renal failure patients.MATERIAL and METHODS: Twenty-two chronic hemodialysis patients, 21 chronic peritoneal dialysis patients, and 16 healthy controls were included in the present study. The levels of serum prohepcidin (the precursor form of hepcidin), high sensitivity C-reactive protein (hs-CRP), troponin-T (TT), and cystatin C (CC) were determined using commercial kits. The left ventricular mass index (LVMI) was estimated using echocardiography.RESULTS: The levels of the CVD risk markers TT, CC, and prohepcidin differed, with statistical significance, between the patient and control groups. Prohepcidin level was significantly associated with CC concentration (β=0.855, R2=0.73, p
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