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The relationship of Extracellular- Superoxide Dismutase enzyme (EC-SOD) with oxidized- low density lipoprotein in type 2 diabetes with macro and normoalbuminuria

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Author(s): Asgarani F | Khajeali L | Esfahanian F | Vosogh MH | Esteghamati AR | Nakhjavani M

Journal: Tehran University Medical Journal
ISSN 1683-1764

Volume: 67;
Issue: 9;
Start page: 608;
Date: 2009;
Original page

Keywords: Diabetes mellitus | oxidized- LDL | extracellular-SOD | proteinuria

ABSTRACT
"nBackground: Increased rate of oxidative stress have important role in diabetic nephropathy. Oxidative stress induces the synthesis of antioxidant enzymes. One of them, Extracellular- SOD (EC–SOD) is a major anti-oxidative enzyme and the only one that neutralizes superoxide ion, a precursor of reactive oxygen species (ROS). The aim of this study was to evaluate the correlation between diabetes- associated oxidative stress and antioxidative defense in macroalbuminuric type 2 diabetic patients. "n"nMethods: One hundred and thirty three patients (74 women, 59 men) with type 2 diabetes were studied during 1385-86. According to level of urinary protein, two groups of patients; normoalbuminuric (urinary protein excertion below 30mg/24h) and macroalbuminuric (urinary protein excretion more than 300mg/24) were recognized. In each group serum level of oxidized- LDL and EC-SOD were measured. "n"nResults: The mean age of patients and the mean duration of diabetes was 59.09±8.26 years and 137.92±65.91 months, respectively. The plasma oxidized-LDL level and extracellular- superoxide dimutase level were significantly higher in macroalbuminuric than normoalbuminuric group (88.57±33.36 versus 78.24±27.59u/l, p=0.039 for oxidized-LDL and 87.60±21.18 versus 76.25±16.25mu/l, p
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