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Release of Bacteriocins from Nanofibers Prepared with Combinations of Poly(D,L-lactide) (PDLLA) and Poly(Ethylene Oxide) (PEO)

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Author(s): Tiaan Heunis | Osama Bshena | Bert Klumperman | Leon Dicks

Journal: International Journal of Molecular Sciences
ISSN 1422-0067

Volume: 12;
Issue: 4;
Start page: 2158;
Date: 2011;
Original page

Keywords: bacteriocins | electrospinning | nanofiber | antimicrobial activity

ABSTRACT
Plantaricin 423, produced by Lactobacillus plantarum, and bacteriocin ST4SA produced by Enterococcus mundtii, were electrospun into nanofibers prepared from different combinations of poly(D,L-lactide) (PDLLA) and poly(ethylene oxide) (PEO) dissolved in N,N-dimethylformamide (DMF). Both peptides were released from the nanofibers with a high initial burst and retained 88% of their original antimicrobial activity at 37 Ā°C. Nanofibers have the potential to serve as carrier matrix for bacteriocins and open a new field in developing controlled antimicrobial delivery systems for variousĀ applications.
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