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Remifentanil and conventional laryngoscopy and tracheal intubation

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Author(s): Vicković Sanja | Pjević Miroslava | Stanisavljević Snežana

Journal: Medicinski Pregled
ISSN 0025-8105

Volume: 60;
Issue: 11-12;
Start page: 593;
Date: 2007;
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Keywords: Intubation | Intratracheal | Laryngoscopy | Analgesics | Opioid | Thiopental | Piperidines | Hemodynamics

ABSTRACT
Introduction. Laryngoscopy and tracheal intubation in patients undergoing surgical procedures under balanced general endotracheal anesthesia may provoke a sympathetic response with tachycardia and hypertension. Material and Methods. Various pharmacological agents, such as anesthetics, analgesics, adrenergic blockers, can modify the hemodynamic response. This investigation evaluated the effects of three different doses of remifentanil on the cardiovascular response to laryngoscopy and orotracheal intubation. The study included 100 patients of both sexes, aged between 21 and 64 years, undergoing various types of surgical procedures under general anesthesia. Patients received remifentanil just before the initiation of anesthesia, and thiopental was used for induction of anesthesia. Results and Conclusion. The results of this investigation indicate that intravenous bolus dose of remifentanil of 0.5mg/kg, combined with thiopental, reduces the cardiovascular response to laryngoscopy and tracheal intubation, whereas bolus doses of remifentanil, 1 and 1.5 mg/kg, provide cardiovascular stability, as well as safe and efficient induction of anesthesia.
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