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Renoprotection by Telmisartan versus Benazepril in Streptozotocin Induced Diabetic Nephropathy

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Author(s): Salil Budhiraja | J. Singh | H Lal | B R Arora

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 5;
Issue: 2;
Start page: 135;
Date: 2006;
Original page

Keywords: Diabetic nephropathy | STZ | Telmisartan | Benazepril

ABSTRACT
Diabetic nephropathy (DN) is one of the major causes of end stage renal disease. Angiotensin converting enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) are preferred for delaying progression of DN. This study compared the preventive renal effects of telmisartan (10 mg/kg, p.o.), an ARB that completely blocks angiotensin action, and benazepril (5 mg/kg, p.o.), an ACE inhibitor, which is a partial blocker of angiotensin II production, in an animal model of diabetic nephropathy. DN is induced by streptozotocin (50 mg/kg, i.p.) single injection in male albino rats. Biochemical parameters (creatinine clearance, urinary protein and blood urea) were significantly (p
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