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Report on open multicentral research program “PRIORITY” in clinical practice (Pektrol — quality of life in patients with stable angina pectoris treated with isosorbide-5-mononitrate in long-acting presentation)

Author(s): Yu.A. Karpov

Journal: Racionalʹnaâ Farmakoterapiâ v Kardiologii
ISSN 1819-6446

Volume: 2;
Issue: 4;
Start page: 25;
Date: 2006;
Original page

Keywords: ischemic heart disease | angina | quality of life | isosorbide-5-mononitrate

Aim. In multicentral program PRIORITY to estimate the efficacy of antianginal therapy after switching patients with stable angina from therapy with short-acting nitrates or isosorbide dinitrate in long-term acting formulation to therapy with isosorbide-5-mononitrate (Pectrol, KRKA, Slovenia) in once daily administrated presentation.Materials and methods. PRIORITY program was held in out-patient clinics of 14 cities.286 patients with stable angina, who took short-acting nitrates or isosorbide dinitrate in long-term acting formulation, were included in research. Patients were switched without any break to the therapy with isosorbide-5-mononitrate (ISMN) in doze of 40 mg once a day, concomitant therapy was not changed. Initially and after 3 months of treatment with ISMN angina functional class, current therapy with nitrates and concomitant therapy were defined. Quality of life was also determined by questionnaire.Results. 275 patients finished program and 261 of them were completely corresponded to the study protocol. The treatment with ISMN reduced the frequency and duration of angina attacks (p
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