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Reproducibility and dose dependency of the antitumoral pharmacodynamic effect of some autochthonous polysaccharidic or polyphenolic biopreparations of fungal and vegetal origin

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Author(s): Cosmin Mihai | Pincu Rotinberg | Daniela Gherghel | Elena Truta | Gabriela Capraru | Ruxandra Cretu | Ion Neacsu | Hellen Rotinberg

Journal: Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara
ISSN 1582-3571

Volume: 9;
Issue: 4;
Date: 2008;
Original page

ABSTRACT
The impact of polysaccharidic or polyphenolic biopreparations – characterized in vitro as cytotoxic and cytostatic agents – upon the carcinogenesis process has been investigated by in vivo successive testing of their effects on the development of Guérin T-8 lymphotropic epitelioma and Walker 256 carcinosarcoma. The similarity of mean tumoral regressions, of the T/C ratios ( between mean tumoral weights of the treated and control groups ), of the T/C values products of the successive retests – registered after the polysaccharidic or polyphenolic treatment - with the evaluation indices standard values, as well as the including of the retests T/C x 100 values between the limits of the admissible variability range have highlighted the reproducibility of their antineoplastic effect. Also, the significance of the antitumoral action of the studied biopreparations upon the rats bearing diverse experimental tumoral lines has been appreciated in relation with the therapeutic effect of different doses on carcinogenesis, as well as from point of view of the experimental oncostatic activity of some standard cytostatics of clinical use (methotrexate, cyclophosfamide, melphalan and 5-fluorouracil). The laboratory treatment with the polyphenolic agents in various doses – superior and inferior to that which has conditioned the expression of their antitumoral effect upon Guerin T-8 lymphotropic epithelioma and Walker 256 carcinosarcoma – has demonstrated the antineoplastic effectiveness` dependence of these biopreparations on the therapeutic dose. The comparative analysis of the evaluation indices values of the antitumoral pharmacodynamic effect – registerd by us in the experimental therapy with the polyphenolic extracts and with the reference cytostatic drugs – has revealed that the antitumoral potential of the new autochthonous biopreparations is higher, equal or near to those of the standard oncochemotherapeutics. The reproducibility of the antitumoral impact and possibility of optimization of the antitumoral efficiency by experimental manipulation of the therapeutic doses are relevant for the characterization of the polyphenolic extracts as potential oncochemotherapeutic agents.
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