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Research: DESIGN AND DEVELOPMENT OF FAST DISINTEGRATING TABLET BY VACUUM DRYING TECHNIQUE

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Author(s): N G Raghavendra Rao* | Md Subhan

Journal: Pharmacie Globale : International Journal of Comprehensive Pharmacy
ISSN 0976-8157

Volume: 02;
Issue: 08;
Start page: 1;
Date: 2011;
Original page

Keywords: Fast dissolving tablet Nimodipine | crospovidone | croscarmellose sodium | camphor.

ABSTRACT
Nimodipine is an antihypertensive, calcium channel blocker, vasodilator agent and used in the treatment of various cardiovascular disorders such as angina pectoris, cardiac arrhythmia and hypertension. Oral bioavailability of nimodipine is around 13% and having half life 9 hrs. In present research work an attempt has been made to prepare fast dissolving tablets of nimodipine by vacuum drying technique. The blend was examined for the pre-compressional parameters and post-compressional parameters. Drug compatibility with excipients was checked by FTIR and DSC studies. No chemical interaction between drug and excipients was confirmed by DSC and FTIR studies. The values of pre-compression parameters evaluated were within prescribed limits and indicated good free flowing property. All the post-compressional parameter are evaluated were prescribed limits and results were within IP acceptable limits. The results obtained showed that quantity of camphor significantly affect the response variables (P> 0.05). The formulations SBP2, SBC2, SBP3 and SBC3 shows less in vitro disintegration time 12.87, 13.48, 11.34 and 12.07 sec respectively. The in-vitro drug release showed 90 % drug released within 5 min. This data reveals that overall, the formulation SBP3 and SBC3 shows nearly faster drug release. The stability study conducted as per the ICH guidelines and the formulations were found to be stable. The results revealed that tablets prepared by the vacuum drying technique using 15 % camphor (SBP3) significantly enhanced the dissolution rate of drug. The results concluded that fast dissolving tablets of Nimodipine showing enhanced dissolution rate may lead to improved bioavailability and effective therapy by using vacuum drying technique.
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