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Research: FAST DISSOLVING ROXITHROMYCIN TABLETS CONTAINING SOLID DISPERSION OF ROXITHROMYCIN

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Author(s): S Muralidhar* | K Kirankumar | M Krishnamurthy | K Kranthiteja | Syedkhajanawaj | T V Narayana

Journal: Pharmacie Globale : International Journal of Comprehensive Pharmacy
ISSN 0976-8157

Volume: 02;
Issue: 09;
Start page: 1;
Date: 2011;
Original page

Keywords: Roxithromycin | Solid dispersion | Physical mixtures | Melt Solvent method | Melting method | Commercial formulation.

ABSTRACT
Roxithromycin, is one of the macrolid antibiotics for respiratory infections.It is slightly soluble in water, hence present study was carried out to enhance dissolution properties of Roxithromycin. Through the preparation of Solid Dispersions using Mannitol as carrier at various proportions (1:1,1:2,&1:4) by using different techniques like Physical mixtures, Melt Solvent and Melting method. The drug release profile was studied in 900ml of distilled water. UV Spectrophotometer method was selected for assay as well as in-vitro dissolution studies at 203 nm. The dispersions were evaluated for drug content uniformity, dissolution rate study; DE20, T50.The FTIR and DSC were used to characterize the solid state of solid dispersions. A marked increase in dissolution rate was observed with all solid dispersions among that the optimized solid dispersion was selected for tablet formulation.
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