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Research: FOMULATION, PHYSICAL CHARECTERISATION AND In-vitro RELEASE STUDIES OF PREDNISOLONE ALGINATE BEADS FOR COLON TARGETING BY IONOTROPIC GELATION

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Author(s): Bagyalakshmi* J | Arun Raj R | Ravi T K

Journal: Pharmacie Globale : International Journal of Comprehensive Pharmacy
ISSN 0976-8157

Volume: 02;
Issue: 03;
Start page: 1;
Date: 2011;
Original page

Keywords: Prednisolone | alginate | beads | colon-specific | Eudragit S-100 | scanning electron microscopy.

ABSTRACT
This article shall give an overview on drug delivery systems for new therapeutic strategies in the treatment of inflammatory bowel disease. Conventional drug delivery systems are tightly adapted from developments of colonic delivery by oral administration triggered by release mechanism owing to the physiological environment that these systems encounter in the colonic region. The newer developments in this context aim for an increased selectivity of drug delivery by targeting mechanisms which have a closer relation to patho physiological particularities of the disease. The objective of the present study was to microencapsulate the anti inflammatory drug (prednisolone) to provide controlled release and colon targeting. Alginate beads of prednisolone were formulated by ionotropic gelation and further coated with Eudragit S-100 and the variables studied includes concentration of sodium alginate, different cross linking agents were evaluated with respect to particle size, surface characteristics entrapment efficiency and in vitro release behavior. IR spectroscopic study confirmed the absence of any drug interaction. DSC analysis revealed that the drug was uniformly dispersed in the alginate beads. The mean particle size increases with increasing the polymer concentration. The shape of alginate beads has acceptable sphericity and surfaces were rough which were confirmed by SEM photograph. The entrapment efficiency in different formulation varied from 69% to 81%. The in vitro release profiles were also altered significantly by changing various parameters. The kinetic modeling of the release data indicates that prednisolone released from alginate beads followed by Korsemeyer’s model. The above observations suggest that prednisolone can be developed as colon targeting drug delivery system with sodium alginate 2.5% using Calcium chloride as cross linking agent and coated with Eudragit S-100.
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