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Research: FREE RADICAL SCAVENGING AND HEPATOPROTECTIVE ACTIVITY OF Aegle marmelos (Linn.) CORR LEAVES AGAINST CARBON TETRACHLORIDE

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Author(s): Nadeem Ahmad Siddique* | Mohd Mujeeb | Abul Kalam Najmi | A Aftab | Junaid Aslam

Journal: Pharmacie Globale : International Journal of Comprehensive Pharmacy
ISSN 0976-8157

Volume: 02;
Issue: 08;
Start page: 1;
Date: 2011;
Original page

Keywords: Aegle marmelos | Antioxidant | Hepatoprotective activity.

ABSTRACT
Aegle marmelos L. belongs to the family Rutaceae; an important medicinal plant being used in the folk therapy. Itis the most useful medicinal plant of India. Its medicinal properties have been described in the ancient medicalliterature. All parts of the tree (stem, bark, root, leaves and fruit at all stages of maturity) have medicinal virtuesand have been used as medicine for a long time. A number of chemical constituents have been isolated fromvarious plant parts including alkaloids, coumarin and steroids. The leaves contain skimianinc, sterol andaegelin. In the present investigation antioxidant and hepatoprotective activity of the methanolic extract of A.marmelos leaves (MEAML) was examined on carbon tetrachloride (CCl4) intoxicated rats. MEAML holdconsiderable amount of phenolic (9.8367±0.0235 mg/kg) and flavonoid (8.248 ± 0.029 mg/kg) contents, whichconfirmed the antioxidant property of the leaves. The MEAML with different doses (50, 100, 200 mg/kg bodyweight) and standard silymarin (40 mg/kg body weight) were orally administered to CCl4 treated rats and theeffect was studied on serum enzymes [(aspartate transaminase (AST), alanine transaminase (ALT), alkalinephosphatase (ALP), and bilurubin, protein, albumin, thiobarbutiric acid (TBARS), reduced glutathione (GSH)]. Inaddition, in-vitro antioxidant activity of MEAML was also evaluated using 1, 1-diphenyl-2-picryl hydrazyl(DPPH) radical. We noticed a significant hepatoprotective activity of MEAML on CCl4 intoxicated rats whichsupport folkloric utilisation of A. marmelos, and it was further confirmed by the histological investigation. Thefindings of the present investigation revealed that the MEAML possess significant hepatoprotective activity bysuppressing CCl4 induced cellular oxidative stress.
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