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The Research Progress about Wnt Pathway of Lung Cancer Stem Cells

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Author(s): Xiaojiang LI | Yingjie JIA | Wenzhi ZHANG | Ying ZHANG | Baole LI | Minna HUANG | Fangfang BAO | Jianguo WU | Yi LOU

Journal: Chinese Journal of Lung Cancer
ISSN 1009-3419

Volume: 14;
Issue: 8;
Start page: 695;
Date: 2011;
Original page

Keywords: Wnt pathway | Lung neoplasms | Stem cells

ABSTRACT
Being the most critical signaling molecule in the Wnt pathway, the Wnt/β-catenin signaling pathway plays an important role in the maintenance of the cell proliferation and clone formation of lung cancer stem cells. Since it is closely related to the WNT pathway, the proliferation of lung cancer stem cells can be restrained by blocking the WNT pathway or influencing its key protein. Such method provides a new method for the treatment of lung cancer. By summarizing the state of-the-art research of lung cancer stem cells and the Wnt pathway from 2005 to 2010, their relationship is investigated.
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