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Research Progress in Non-small Cell Lung Cancer 
with Concomitant EML4-ALK Fusion Gene and EGFR Gene Mutation

Author(s): Zhu ZENG | Yilong WU

Journal: Chinese Journal of Lung Cancer
ISSN 1009-3419

Volume: 14;
Issue: 11;
Start page: 880;
Date: 2011;
Original page

Keywords: Lung neoplasms | Human EML4-ALK fusion protein | Epidermal growth factor receptor (EGFR)

Lung cancer is one of the most prevalence malignances, of which non-small cell lung cancer (NSCLC) account for 80%-85% of lung cancer. Molecular target therapy is one of the most popular and promising field of NSCLC treatment, and its hotspots includes EGFR (epidermal growth factor receptor), EML4-ALK (echinoderm microtubule associated protein like4-anaplastic lymphoma kinase), etc. Former researches indicated that EML4-ALK fusion and EGFR mutation were excluded mutually. However, cases of patients harbored concomitant EML4-ALK fusion gene and EGFR mutation have been reported continuously at recent. This review aims to summarize the incidence and molecular structure of EML4-ALK fusion gene and EGFR mutation, as well as clinical features of patients with the concomitant genes induced NSCLC.
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