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Research: PROTECTIVE EFFECT OF ATORVASTATIN AGAINST VANCOMYCIN INDUCED NEPHROTOXICITY IN ALBINO RATS

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Author(s): Rajitha Panonnummal* | Joyamma Varkey | Dinoop D R

Journal: Pharmacie Globale : International Journal of Comprehensive Pharmacy
ISSN 0976-8157

Volume: 02;
Issue: 08;
Start page: 1;
Date: 2011;
Original page

Keywords: Vancomycin | nephrotoxicity | BUN | atorvastatin | oxidative stress.

ABSTRACT
Objective: To investigate the effect of atorvastatin on vancomycin induced nephrotoxicity in rats. Method: Wistar rats of either sex were divided into 4 groups; they received distilled water, vancomycin 200mg/kg ip twice daily for 7 days, atorvastatin 10mg/kg for 5 days and along with vancomycin for 7 days followed by 5 more days, 0.5% Carboxy methyl cellulose (CMC) at a dose of 0.5ml/100g for 5 days and along with vancomycin for 7 days followed by 5 more days. Renal function tests like BUN, serum creatinine, creatinine clearence, kidney malon dialdehyde (MDA), glutathione(GSH), superoxide dismutase (SOD), catalse, urine sodium and potassium, serum potassium, body weight changes, kidney weight and renal histopathology were monitored after various treatment. Statistical analysis was done through oneway ANOVA with post hoc Tokey Test. Result: Vancomycin induced nephrotoxicity was evidenced by significant elevation in Blood Urea Nitrogen (BUN), serum creatinine and diminished creatinine clearance. Treatment with atorvastatin caused a significant decrease in elevated BUN and serum creatinine and raised the diminished creatinine clearance. Lipid peroxidation products MDA were markedly increased by vancomycin, which was significantly reduced by atorvastatin. Down regulated antioxidant enzymes SOD, catalase, and GSH associated with vancomycin use was markedly antagonized by atorvastatin treatment. Altered urine electrolyte by vancomycin use was also normalized by atorvastatin use. Renal histopathology revealed marked glomerular and tubular damages in vancomycin treated rats; whereas treatment with atorvastatin attenuated most of the tubular changes and glomerular changes. Conclusion: It was concluded that atorvastatin exhibits a protective role against vancomycin induced renal damage by antagonizing renal oxidative stress associated with vancomycin use.
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