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Research: STUDY OF ENHANCEMENT OF DISSOLUTION RATE OF CARBAMAZEPINE BY SOLID DISPERSION

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Author(s): Renu Kalyanwat* | Stuti Gupta | Rajendra Kr Songara | Dolly Jain | Sushma Patel

Journal: Pharmacie Globale : International Journal of Comprehensive Pharmacy
ISSN 0976-8157

Volume: 02;
Issue: 05;
Start page: 1;
Date: 2011;
Original page

Keywords: Carbamazepine | croscarmellose sodium | sodium starch glycolate | dissolution apparatus | UV spectrophotometer.

ABSTRACT
The purpose of this study is to enhance the dissolution rate of carbamazepine by solid dispersion. This solid dispersion of carbamazepine was prepared by modified solvent evaporation method. Two types of superdisintegrants croscarmellose sodium and sodium starch glycolate were incorporated. Then prepared different batches of solid dispersion were evaluated by drug content determination, saturation solubility study and dissolution study. Thus dissolution rate of carbamazepine was found to be increasing with superdisintegrant addition.
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