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Research: SYNTHESIS, ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF SOME MANNICH BASES OF 6-SUBSTITUTED-2-AMINOBENZOTHIAZOLE

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Author(s): Bele D S* | Singhvi I

Journal: Pharmacie Globale : International Journal of Comprehensive Pharmacy
ISSN 0976-8157

Volume: 02;
Issue: 10;
Start page: 1;
Date: 2011;
Original page

Keywords: 1H-1 | 2 | 4-triazole | 2-aminobenzothiazole | Mannich base | analgesic | anti-inflammatory.

ABSTRACT
Ten new mannich bases were synthesized by condensation of equimolar quantities of corresponding 6-substituted-2-aminobenzothizole derivatives with 1-(5-substituted-1H-1,2,4-triazol-1-yl)-ethanone derivatives in presence of formaldehyde and concentrated hydrochloric acid. The purity and homogeneity of the synthesized compounds was routinely checked by TLC using solvent systems Benzene: methanol (50:50 v/v) and Carbon tetrachloride: methanol (50:50 v/v). All the synthesized compounds were characterized by FT-IR and 1H-NMR spectroscopy. The synthesized compounds were screened for analgesic and anti-inflammatory activity. Few compounds exhibit excellent activities as compared to the standard drugs.
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