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Respuesta de ratones Balb/c frente a ciclofosfamida y bleomicina en el ensayo de la morfología de la cabeza del espermatozoide - Balb/c mice’s response against bleomycin and cyclophosphamide in the head sperm morphology assay

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Author(s): Arencibia Arrebola Daniel Franciscoa | Rosario Fernández Luis Alfredo

Journal: REDVET
ISSN 1695-7504

Volume: XII;
Issue: 2;
Date: 2011;
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Keywords: Bleomicina | ciclofosfamida | ensayo de la morfología de la cabeza del espermatozoide | ratones Balb/c. | Bleomycin | cyclophosphamide | head sperm morphology assay | Balb/c mice.

ABSTRACT
ResumenEl ensayo de la morfología de la cabeza del espermatozoide permite el estudio del potencial genotóxico de muestras problemas a nivel celular. En este artículo se decidió evaluar y comparar en 16 ratones Balb/c machos por grupo, el efecto de dos sustancias mutagénicas en este ensayo.SummaryThe head sperm morphology assay, allows the study of the genotoxic potencial of samples at the cellular level problems. In this article we decide to evaluate and to compare in 16 Balb/c males mice per group, the effect of two mutagenic substances in these assay, the Cyclophosphamide (CF) in dose of 50 mg/kg and the Bleomycin (BL) in dose of 20 mg/kg, administered by intraperitoneal route during 5 consecutive days, being sacrificed the animals 35 days after the last administration of the mutagens.
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