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Resveratrol: An Antiaging Drug with Potential Therapeutic Applications in Treating Diseases

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Author(s): Antoni Camins | Felix Junyent | Ester Verdaguer | Carlos Beas-Zarate | Argelia E. Rojas-Mayorquín | Daniel Ortuño-Sahagún | Mercè Pallàs

Journal: Pharmaceuticals
ISSN 1424-8247

Volume: 2;
Issue: 3;
Start page: 194;
Date: 2009;
Original page

Keywords: resveratrol | Alzheimer’s disease | Parkinson’s disease | SIRT1

ABSTRACT
The prevention of aging is one of the most fascinating areas in biomedicine. The first step in the development of effective drugs for aging prevention is a knowledge of the biochemical pathways responsible for the cellular aging process. In this context it seems clear that free radicals play a key role in the aging process. However, in recent years it has been demonstrated that the families of enzymes called sirtuins, specifically situin 1 (SIRT1), have an anti-aging action. Thus, the natural compound resveratrol is a natural compound that shows a very strong activation of SIRT1 and also shows antioxidant effects. By activating sirtuin 1, resveratrol modulates the activity of numerous proteins, including peroxisome proliferator-activated receptor coactivator-1α (PGC-1 alpha), the FOXO family, Akt (protein kinase B) and NFκβ. In the present review, we suggest that resveratrol may constitute a potential drug for prevention of ageing and for the treatment of several diseases due to its antioxidant properties and sirtuin activation.
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