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Retrospective analysis of 286 Brucellosis cases in the southeast of Turkey

Author(s): Recep Tekin | Zehra Çağla Karakoç | Özlem Demirpençe | Fatma Bozkurt | Özcan Deveci | Duygu Mert

Journal: Journal of Clinical and Experimental Investigations
ISSN 1309-8578

Volume: 3;
Issue: 3;
Start page: 335;
Date: 2012;
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Keywords: Brucellosis | Southeastern Anatolia | Turkey

Objectives: The aim of this study was to evaluate theclinical, laboratory findings and therapeutic features ofthe patients inhabiting in Diyarbakır, Mardin and Batmanprovince, in Southeastern Anatolia of Turkey.Materials and methods: In this study, 286 patients withbrucellosis, followed in departments of infectious diseasesand clinical microbiology between June 2007 and July2009, were evaluated retrospectively.Results: One hundred fifty six (55%) of the patients werefemale and 130 (45%) were male. Mean age was 32.8 +15.3 (range15-78) years. The patients were categorizedas acute (75%), subacute (23%) and chronic (2%) brucellosis.Major transmission route was the consumption ofunpasteurized fresh cheese. The transport of animals inthe region is not controlled. Malaise, fever, myalgia arthralgiaand sweating were the most frequently observedsymptoms. The most common signs were fever 90.8%,arthritis 54.1%, splenomegaly 18.3% and hepatomegaly11%. The most frequent laboratory finding was a high Creactiveprotein level (60%). Diagnosis was made basedon the clinical features and positive Rose-Bengal testcombination with an initial Brucella antibody titer greaterthan or equal to 1/160. The most frequently preferred antimicrobialregimen was rifampin and doxycycline combination.Conclusions: Brucellosis is still an important publichealth problem in Turkey. The disease has an importantmorbidity and mortality. Brucellosis should be kept inmind in endemic regions of our country with the symptomsof fever, leukopenia and osteoarticular symptoms. JClin Exp Invest 2012; 3 (3): 335-339Key words: Brucellosis, Southeastern Anatolia, Turkey.
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