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Reverse phase high performance liquid chromatography method for estimation of ezetimibe in bulk and pharmaceutical formulations

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Author(s): Akmar S | Kothapalli Lata | Thomas Asha | Jangam Sumitra | Deshpande A

Journal: Indian Journal of Pharmaceutical Sciences
ISSN 0250-474X

Volume: 69;
Issue: 5;
Start page: 695;
Date: 2007;
Original page

Keywords: Ezetimibe | RPHPLC

ABSTRACT
A rapid, precise, economical and accurate HPLC method for estimation of ezetimibe in bulk and pharmaceutical formulations has been developed. The chromatographic resolution of ezetimibe was achieved using acetonitrile:0.02 M potassium dihydrogen orthophosphate buffer (72:28 v/v) as the mobile phase with UV detection at 232 nm and C8 kromasil 5 μ column. The flow rate was 1 ml/min. Results of the analysis were validated statistically and by recovery studies and were found to be satisfactory.
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