Academic Journals Database
Disseminating quality controlled scientific knowledge

Review: Colchicine, current advances and future prospects

ADD TO MY LIST
 
Author(s): RAVINDRA ADE | MAHENDRA KUMAR RAI

Journal: Nusantara Bioscience
ISSN 2087-3948

Volume: 2;
Issue: 2;
Start page: 90;
Date: 2010;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: colchicine | photoisomerization | colchicinamide | toxicity | polyploidy

ABSTRACT
Abstract. Ade R, Rai MK. 2010. Colchicine, current advances and future prospects. Nusantara Bioscience 2: 90-96. Colchicine is a toxic natural compound and secondary metabolite commonly produced by plants like Colchicum autumnale and Gloriosa superba. It is originally used to treat rheumatic complaints, especially gout, and still finds its uses for these purposes today despite dosing issues concerning its toxicity. It is also prescribed for its cathartic and emetic effects. Initially oral colchicine has not been approved as a drug by U.S. Food and Drug Administration (FDA). But now FDA approved colchicine as a drug for some disorders. Colchicine's present medicinal use is in the treatment of gout and familial mediterranean fever. It is also being investigated for its use as an anticancer drug. In neurons, axoplasmic transport is disrupted by colchicine. Due to all the pharmacological application of colchicine, there is urgent need to enhance the properties and increase the production of colchicine with the help of in vitro technologies. The present review is mainly focused on the chemistry of colchicine, its medicinal uses and toxicity.
Save time & money - Smart Internet Solutions     

Tango Jona
Tangokurs Rapperswil-Jona