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A REVIEW ON SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM: AN APPROACH TO ENHANCE THE ORAL BIOAVAILABILITY OF POORLY WATER SOLUBLE DRUGS

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Author(s): Shukla Prachi | Prajapati S.K | Sharma Upendra K | Shivhare Shipra | Akhtar Ali

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 3;
Issue: 9;
Start page: 1;
Date: 2012;
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Keywords: Self microemulsifying drug delivery system (SMEDDS) | lipid based drug delivery systems | oral bioavailability | poorly water soluble drugs.

ABSTRACT
Technology Catalysts International reported in 2002 that approximately 35-40% of all new chemical compounds suffer from poor aqueous solubility and present a major challenge to modern drug delivery system, because of their low oral bioavailability. Several strategies to improve the solubility and dissolution of poorly water soluble drugs have been developed, which were at start primarily based on modifying the drug’s physicochemical properties. Realization that the oral bioavailability of poor water soluble drugs may be enhanced when co-administered with meal rich in fat has led to increasing recent interest in the formulation of poorly water soluble drugs in lipids. Lipid-based drug delivery systems have gained considerable interest after the commercial success of Sandimmune NeoralTM (Cyclosporine A), Novartis Pvt. Ltd. and Fortovase (Saquinavir), Roche Laboratories Inc. Self micro-emulsifying drug delivery systems are a class of lipid based drug delivery systems. Self micro emulsifying drug delivery systems are isotropic mixtures of oil, surfactant, and co-surfactant and are a vital tool in solving low bioavailability issues of poorly soluble drugs. Lipophilic drugs can be dissolved in these systems, enabling them to be administered as a unit dosage form for per-oral administration. When such a system is released in the lumen of the gastrointestinal tract, it disperses to form a fine w/o microemulsion with the aid of GI fluid. This leads to in situ solubilization of drug that can subsequently be absorbed by lymphatic pathways, bypassing the hepatic first-pass effect. This article represents a complete review on self micro-emulsifying drug delivery system.
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