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Rola kinazy syntazy glikogenu 3β w chorobach ośrodkowego układu nerwowego

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Author(s): Jan K. Nowak

Journal: Neuropsychiatria i Neuropsychologia
ISSN 1896-6764

Volume: 6;
Issue: 1;
Start page: 25;
Date: 2011;
Original page

Keywords: GSK3β | affective disorders | schizophrenia | Alzheimer disease | neurogenesis

ABSTRACT
The β isoform of glycogen synthase kinase 3 enzyme(GSK3β), which is found at particularly highconcentrations in the central nervous system, is crucialfor its proper development and functioning. The role ofGSK3β in the pathogenesis of affective disorders,schizophrenia and Alzheimer’s disease, as well as itsinvolvement in other neurological disorders andneurogenesis, is discussed. A hypothesis is proposed thatinhibitory phosphorylation of GSK3β induced bynon-selective cyclooxygenase (COX) inhibitors mediatesthe non-selective COX inhibitors’ Alzheimer’s diseaseand Parkinson’s disease risk-lowering effects.Throughout the review special attention is paid tothe therapeutic potential of GSK3β inhibitors.Supplementary information on GSK3β cellular activityregulation, the place of GSK3β in the Wnt signallingpathway, the link between GSK3β and memory,neuroplasticity and circadian rhythms is provided.

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