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Role of annexin II in pancreatic and colon cancer cell growth promotion

Author(s): Agata Ptak-Belowska | Aneta Targosz | Gracjana Krzysiek-Mączka | Tomasz Brzozowski | Wiesław W. Pawlik

Journal: Polish Gastroenterology
ISSN 1232-9886

Volume: 17;
Issue: 3;
Start page: 204;
Date: 2010;
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Keywords: annexin II | gastrin | colon cancer | pancreatic cancer

Introduction: Gastrin exerts growth stimulatory and co-carcinogenic effects in gastrointestinal (GI) tract. Gastrin peptide mediates its growth effects by binding to CCK1 and CCK2 receptors. However, recently annexin II (ANX II) has been identified as a high affinity binding protein for gastrin and its precursors. It's known that ANX II binds gastrin and mediates some growth factor effects on GI cancer cells. Aim of the study: We assessed the role and possible interactions between ANX II and gastrin in growth of colon and pancreatic cancer cells. Human pancreatic and colon cancer cell lines in in vitro models were investigated. Material and methods: The human pancreatic, colon cancer cell lines were used. Cancer cell lines with or without treatment with gastrin were investigated in terms of protein level of ANX II by Western Blot method. Growth effects exerted by hormone gastrin were assessed using MTT assay method. Results and conclusions: Gastrin peptide promotes colon and pancreatic cancer cells growth and leads to an increase in ANX II protein expression in these cells.
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