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ROLE OF HEMATOLOGICAL PARAMETERS IN DIAGNOSIS AND PROGNOSIS OF GASTRIC CARCINOMA IN KASHMIR, INDIA

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Author(s): Rabia Farooq | Arif Akbar Bhat | Hilal Ahmad Wani | Hamid Bashir | Nisar Ahmad Naikoo | Shajrul Amin | Bashir Ahmad Ganai | Sabhiya Majid

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 4;
Issue: 8;
Start page: 134;
Date: 2013;
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Keywords: Gastric cancer | Hematological parameters | CEA | SMHS.

ABSTRACT
Gastric cancer is the second leading cause of death in the world. More than two-thirds of the patients are diagnosed at an advanced stage. Metastatic gastric cancer has poor prognosis with a median 5 years-survival rate of 7 %. Hematological parameters including leukocyte count, platelet count and their ratios have been used as prognostic indicators in several tumor types. The aim of the study was to examine an association of the difference in haematological parameters between gastric cancer patients and normal controls of Kashmir valley. We enrolled 210 subjects of which 110 were newly diagnosed gastric cancer cases and 100 were healthy controls. Participants were recruited from hospitals, clinics and radiology department of Shri Maharaja Hari Singh (SMHS) hospital Srinagar, India from May 2011 to Apr 2012. After informed consent, all patients were interviewed and examined and demographic and clinical information was collected. Blood samples were drawn for examination of hematological measures and for measurement of carcino embryonic antigen (CEA). We found the hematological parameters like: Hb (10 ± 2, P = 0.004), MCV (84.25 ± 5, p = 0.01), Granulocyte % (70.04 ± 10.63, p = 0.001), Lymphocyte % (26.12 ± 10.7, p < 0.0001), RDW (48 ± 10, p = 0.004) in gastric cancer patients and these were found to be highly decreased as compared to normal healthy controls where hematological parameters was in normal range. Our study was statistically significant (p < 0.005). The study suggests that the hematological parameters like HB, MCV, Granulocyte %, Lymphocyte % and RDW are decreased in gastric cancer patients and acts as an early marker in the prognosis and diagnosis of gastric cancer.
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