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The Role of HER2 in Metastatic Breast Cancer Treated with a Combination of Taxanes and Cisplatin

Author(s): Hung-Chih Hsu | Hsien-Kun Chang | Yung-Chang Lin | Sheu Hseu | Jen-Shi Chen | Tsai-Shen Yang | Hung-Ming Wang | Wen-Chi Shen

Journal: Chang Gung Medical Journal
ISSN 2072-0939

Volume: 32;
Issue: 01;
Start page: 33;
Date: 2009;
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Keywords: breast cancer | taxanes | cisplatin | HER2 | chemotherapy

Background: A combination of taxanes and cisplatin have shown modest activity as second-line chemotherapy in breast cancer patients who have been exposed toanthracyclines. The purpose of this study was to retrospectively assesswhether HER2 is associated with clinical sensitivity or with prognostic significancein breast cancer patient groups who had received chemotherapywith taxanes and cisplatin.Methods: Patients were treated either with docetaxel 60 mg/m2 or paclitaxel 175 mg/m2in combination with cisplatin 50 mg/m2 every 3 weeks. The tumor specimenswere checked for estrogen receptor (ER), progestrone receptor (PR), andHER2 status by immunohistochemical stain. Prognostic factors such as performancestatus, status of metastases, history of prior anthracycline response,and biomarkers such as ER and HER2 were analyzed.Results: Ninety patients were eligible for HER2 assessment. Only eighty-five patientswere eligible for response assessment. The overall response rate tochemotherapy with the taxanes/cisplatin regimen was 52%. In patients whowere HER2-positive, the response rate was 62% and in HER2-negativepatients, it was 46%, p = 0.17. Univariate analysis showed no prognostic factorswere significant in predicting a response to chemotherapy. In addition, itappeared that there was no difference in time to progression and overall survivalbased on HER2 status.Conclusions: Our results indicated that HER2 status is independent of a response to a taxanes/cisplatin combination and is also not a prognostic factor for survival.
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