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The role of Lipoxin A4 in Cystic Fibrosis Lung Disease

Author(s): Valérie Urbach | Gerard Higgins | Paul Buchanan | Fiona Ringholz

Journal: Computational and Structural Biotechnology Journal
ISSN 2001-0370

Volume: 6;
Issue: 7;
Start page: e201303018;
Date: 2013;
Original page

In Cystic Fibrosis (CF), mutations of the CFTR gene result in defective Cl- secretion and Na+ hyperabsorption by epithelia which leads to airway lumen dehydration and mucus plugging and favours chronic bacterial colonization, persistent inflammation and progressive lung destruction. Beyond this general description, the pathogenesis of CF lung disease remains obscure due to an incomplete understanding of normal innate airway defense. This mini-review aims to highlight the role of the pro-resolution lipid mediator, Lipoxin A4, which is inadequately produced in CF, on several aspects of innate immunity that are altered in CF airway disease.
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