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Role Of Mast Cell In Oral Pathology

Author(s): Supriya Kheur | Deepali Patekar | Neeta Bagul | Meena Kulkarni | Samapika Routray | Varsha Dhas

Journal: Oral & Maxillofacial Pathology Journal
ISSN 0976-1225

Volume: 4;
Issue: 1;
Start page: 320;
Date: 2013;
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Keywords: Mast cells | Degranulation | Cytokines | Tryptase | Chymase.

Mast cells in oral tissues releases various pro-inflammatory cytokine tumor necrosis factor alpha (TNF-ά) which promotes leukocyte infiltration in various inflammatory condition of oral cavity such as oral lichen planus (OLP), periapical lesions, gingivitis & periodontitis. T lymphocyte derived cytokines influences mast cell migration & mediator release. Mast cell secreted proteases, activates matrix-metalloprotinases-9 (MMP-9) which may contribute to alteration in basement membrane in inflammatory condition such as Lichen Planus. Hence by understanding the role of mast cells in the pathogenesis of various diseases; therapies should be targeted to enhance the prognosis of the diseases.
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