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The Role of Opioid and α-adrenergic Receptors in the Ileal Antispasmodic Activity of Ruta chalepensis Extract

Author(s): A.A. Moazedi | N. Dabir | M.K. Gharib Naseri | M.R. Zadkarami

Journal: Journal of Biological Sciences
ISSN 1727-3048

Volume: 10;
Issue: 8;
Start page: 779;
Date: 2010;
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Keywords: Ileum | rat | a-adrenergic receptors | Ruta chalepensis | opioid receptors | Antispasmodic

The aim of present study was to investigate the role of opioid and α-adrenergic receptors in antispasmodic activity of Ruta chalepensis (L.) hydroalcoholic extract (RCHE) in rat ileum contractions induced by KCl. A piece of ileum (2 cm) was dissected out from male Wistar rats and mounted in an organ bath containing air bubbled Tyrode solution (37°C). Isotonic Transducer is exceptionally sensitive and stable and connected to Harvard Universal Oscillograph (UK). The tissue was under 1 g initial tension and contractions were recorded isotonically. The RCHE was prepared by macerated with alcohol (70%). Ileum was contracted by KCl (60 mM) and cumulative concentrations of RCHE were applied (0.01-0.07 mg mL-1) before and after tissue incubation (30 min) with naloxon (1 μM) or phentolamine (1 μM). RCHE reduced KCl-induced contraction in a concentration dependent manner (p
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