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Role of Oxidants and Anti Oxidants in Patients with Cardiovascular Diseases

Author(s): Ujjwala Jayant kulkarni | Seema L. Jaw alekar; Vasant T. Surve and Y.A. Deshmukh

Journal: Asian Journal of Medical Sciences
ISSN 2040-8765

Volume: 2;
Issue: 4;
Start page: 181;
Date: 2010;
Original page

Keywords: Glutathione peroxidase | glutathione reductase | lipid peroxidation | Malonyldialdehyde | nitric oxide | oxidative stress | superoxide dismutase

Over the last two decades, it has become increasingly clear that reactive oxygen species (ROS), including free radicals are involved in cardiovascular diseases. In recent years, there has been a growing interest in the clinical implications of these oxidants. The ROS are common by-products of many oxidative biochemical and physiological processes. Therefore the present study was carried out to evaluate the total antioxidant capacity, lipid peroxidation and status of superoxide dismutase in patients with cardiovascular diseases. Total 185 patients of both sexes were included in the study and further classified into 3 groups as hypertensive, Ischemic heart disease and cerebrovascular disease/stroke. The 60 healthy subjects who were not on any kind of prescribed medication or dietary restrictions were included in the control group. MDA is estimated as a marker of lipid peroxidation, levels were significantly increased in all groups than controls (p

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