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The role of a probiotics mixture in the treatment of childhood constipation: a pilot study

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Author(s): Bekkali Noor-L-Houda | Bongers Marloes | Van den Berg Maartje | Liem Olivia | Benninga Marc

Journal: Nutrition Journal
ISSN 1475-2891

Volume: 6;
Issue: 1;
Start page: 17;
Date: 2007;
Original page

ABSTRACT
Abstract Background Inconsistent data exist about the efficacy of probiotics in the treatment of constipation. Several studies in adults with constipation showed positive effects of probiotics on constipation. Inconsistent data exist regarding the effect of a single probiotic strain in constipated children. The aim of this pilot study was to determine the effect of a mixture of probiotics containing bifidobacteria and lactobacilli in the treatment of childhood constipation. Methods Children aged 4–16 years with constipation as defined by the Rome III criteria were eligible for the study. During a 4 week period, children received a daily mix of 4 × 109 colony forming units of a probiotic mixture (Ecologic®Relief) containing Bifidobacteria (B.) bifidum, B. infantis, B. longum, Lactobacilli (L.) casei, L. plantarum and L. rhamnosus. Primary outcome measures were frequency of bowel movements (BMs) per week and stool consistency. Secondary outcome measures were number of faecal incontinence episodes per week, abdominal pain and side effects. Results Twenty children, 50% male, median age 8 (range 4–16) were included. The frequency of BMs per week increased from 2.0 (1.0–5.0) to 4.2 (0.0–16.0) in week 2 (p = 0.10) and 3.8 (2.1–7.0) in week 4 (p = 0.13). In 12 children presenting with

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