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Role of SDF1/CXCR4 Interaction in Experimental Hemiplegic Models with Neural Cell Transplantation

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Author(s): Nagisa Arimitsu | Jun Shimizu | Naruyoshi Fujiwara | Kenji Takai | Erika Takada | Takao Kono | Yuji Ueda | Tomoko Suzuki | Noboru Suzuki

Journal: International Journal of Molecular Sciences
ISSN 1422-0067

Volume: 13;
Issue: 3;
Start page: 2636;
Date: 2012;
Original page

Keywords: neural stem/progenitor cells | chemokines | cell migration | chemokine receptor

ABSTRACT
Much attention has been focused on neural cell transplantation because of its promising clinical applications. We have reported that embryonic stem (ES) cell derived neural stem/progenitor cell transplantation significantly improved motor functions in a hemiplegic mouse model. It is important to understand the molecular mechanisms governing neural regeneration of the damaged motor cortex after the transplantation. Recent investigations disclosed that chemokines participated in the regulation of migration and maturation of neural cell grafts. In this review, we summarize the involvement of inflammatory chemokines including stromal cell derived factor 1 (SDF1) in neural regeneration after ES cell derived neural stem/progenitor cell transplantation in mouse stroke models.
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