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ROLE OF SHODHANA ON ANALYTICAL PARAMETERS OF DATURA INNOXIA MILL AND DATURA METEL LINN SEEDS

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Author(s): Patel Yogesh | Bhat Savitha D. | Acharya Rabinarayan | B. K Ashok | Shukla V.J

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 1;
Issue: 2;
Start page: 249;
Date: 2010;
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Keywords: Dhattura | Shodhana | Physico chemical study | Analytical study | Hyoscyamine | Scopalamine.

ABSTRACT
Dhattura is a well known and frequently used drug in Ayurveda. Since its seeds are considered to be highly toxic, Ayurveda advocates specific procedures called Shodhana (purification procedures) before rendering it into a safe therapeutic drug. The present analytical study was carried out on seeds of two species of Dhattura namely Datura innoxia Mill. and Datura metel Linn. both before and after Shodhana. Parameters like physico-chemical analysis, pH, extractive values, test for various functional groups, thin layer chromatography and GC-MS studies with special reference to hyoscyamine and scopolamine alkaloids were carried out. The Shodhana process resulted in 70 to 90% reduction in hyosciamine content, where as scopolamine content reduced almost to zero. The present study reflects the importance of Shodhana of poisonous plant drugs by means of which one can lessen the toxic constituents.
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