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Role of Synbiotics in the Treatment of Childhood Constipation: A Double-Blind Randomized Placebo Controlled Trial

Author(s): Ahmad Khodadad | Mozhgan Sabbaghian

Journal: Iranian Journal of Pediatrics
ISSN 2008-2142

Volume: 20;
Issue: 4;
Start page: 387;
Date: 2010;
Original page

Keywords: Constipation | Synbiotic | Probiotics | Prebiotics | Paraffin oil

Objective: Constipation is a common problem in children. There is some clinical evidence for the role of probiotics and prebiotics in the treatment of constipated children. This is the first study on the therapeutic effect of synbiotics (combination of probiotics and prebiotic) in treatment of childhood constipation. Methods: In a double-blind randomized placebo controlled study 102 children aged 4-12 years with functional constipation were assessed according to Rome III criteria for 4 weeks. They were divided into 3 groups: Group A, received 1.5 ml/kg/day oral liquid paraffin plus placebo, group B, 1 sachet synbiotic per day plus placebo and group C, 1.5 ml/kg/day oral liquid paraffin plus 1 sachet synbiotic per day. Frequency of bowel movements (BMs), stool consistency, number of fecal incontinence episodes, abdominal pain, painful defecation per week, success of treatment and side effects were determined in each group before and after treatment. Findings: The frequency of BMs per week increased in all groups (P

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