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The Role of Transcription Factors in Cytokine-Mediated Apoptosis of Lymphocytes

Author(s): Olga Evgenevna Saveleva | Larisa Sergeevna Litvinova | Evgeniya Sergeevna Anishchenko | Viacheslav Viktorovish Novitsky | Nataliya Vladimirovna Riazantseva

Journal: International Journal of Biology
ISSN 1916-9671

Volume: 4;
Issue: 1;
Date: 2011;
Original page

The role of transcription factors in the implementation of IL-2 and IL-4 proapoptotic effects investigated in the in vitro experiment. It is shown that recombinant IL-2 at a dose of 0.10 ng/ml and IL-4 at a dose of 0.15 ng/ml have apoptotic effects on lymphocytes. At the apoptosis induction by rIL-2 and rIL-4 the transcription factors NF-kB, p53, pRb and inhibitor of cyclin-dependent kinases p21WAF1/CIP1 are activated.
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