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Ropivacaine: A review of its pharmacology and clinical use

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Author(s): Kuthiala Gaurav | Chaudhary Geeta

Journal: Indian Journal of Anaesthesia
ISSN 0019-5049

Volume: 55;
Issue: 2;
Start page: 104;
Date: 2011;
Original page

Keywords: Anaesthesia | regional anaesthetic | ropivacaine

ABSTRACT
Ropivacaine is a long-acting amide local anaesthetic agent and first produced as a pure enantiomer. It produces effects similar to other local anaesthetics via reversible inhibition of sodium ion influx in nerve fibres. Ropivacaine is less lipophilic than bupivacaine and is less likely to penetrate large myelinated motor fibres, resulting in a relatively reduced motor blockade. Thus, ropivacaine has a greater degree of motor sensory differentiation, which could be useful when motor blockade is undesirable. The reduced lipophilicity is also associated with decreased potential for central nervous system toxicity and cardiotoxicity. The drug displays linear and dose proportional pharmacokinetics (up to 80 mg administered intravenously). It is metabolised extensively in the liver and excreted in urine. The present article details the clinical applications of ropivacaine and its current place as a local anaesthetic in the group.
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