Academic Journals Database
Disseminating quality controlled scientific knowledge

ROSIGLITAZONE MALEATE MICROSPHERES FOR EXTENDING DRUG RELEASE: FORMULATION AND EVALUATION

ADD TO MY LIST
 
Author(s): Ram Chand Dhakar

Journal: International Journal of Pharmaceutical Research and Development
ISSN 0974-9446

Volume: 2;
Issue: 10;
Start page: 8;
Date: 2010;
Original page

Keywords: Rosiglitazone Maleate | Mucoadhesive Microspheres | Diabetes Type-2 | controlled drug delivery | Sodium carboxy methyl cellulose | Carbopol 934.

ABSTRACT
The work was aim to formulate and evaluate mucoadhesive microspheres of Rosiglitazone Maleate for treatment of diabetes type-2 by combine the potential advantages of mucoadhesion with controlled drug delivery using various ratio of polymers. Mucoadhesive microspheres were prepared by emulsification solvent evaporation techniques. Microspheres were found discrete, spherical and free flowing. They ranged in particle size from 21-37 ┬Ám. The microspheres exhibits good mucoadhesive property in in-vitro wash off test and showed high drug entrapment efficiency. Rosiglitazone Maleate release from these microspheres was slowed, extended and depended on the type of polymer used. The formulation F1 and F2 showed consistent drug release for up to 12 h time period. Among all the formulations, F1 containing sodium carboxy methyl cellulose and F2 containing Carbopol 934 showed the reproducible results with best mucoadhesive profile and good surface morphology. The work has demonstrated that among all the formulations of microspheres, particularly those of formulation F1 are promising candidates for the sustained release of Rosiglitazone Maleate in the gastrointestinal tract.
Affiliate Program      Why do you need a reservation system?