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RP-HPLC METHOD FOR ESTIMATION OF QUETIAPINE HEMI FUMARATE IN TABLET DOSAGE FORM

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Author(s): Mohite Mukesh. T | Shinde Swapnil. S | Singh Reema R. N | Wagh Mahesh. B.

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 4;
Issue: 8;
Start page: 211;
Date: 2013;
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Keywords: Quetiapine Hemi Fumarate (QHF) | RP-HPLC.

ABSTRACT
A simple, sensitive, rapid, robust and reproducible method for the determination of Quetiapine Hemi Fumarate (QHF) in bulk and Pharmaceutical Formulation (Tablets) was developed using Reverse Phase High Performance Liquid Chromatographic method (RP-HPLC). The RP-HPLC analysis was performed isocratically on XTERRA C18 (4.6 X 150 mm), analytical column using a mobile phase consisting of Acetonitrile and methanol in the ratio of 60 : 40 v / v, with a flow rate of 1 ml / min. The analyte was monitored with UV detector at 290 nm. The developed method Quetiapine hemi fumarate elutes at a run time of 10 minutes. The proposed method is having linearity in the concentration range from 20 to 100 μg / mL of Quetiapine hemi fumarate. The present method was validated with respect to system suitability, linearity, precision, limit of detection (LOD) and limit of quantification (LOQ), accuracy (recovery), and robustness as per ICH Guidelines. The proposed method can be readily utilized for bulk drug and pharmaceutical formulations.
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