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A RP-HPLC Method for the Estimation of Ritonavir in Pharmaceutical dosage forms

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Author(s): Veera Venkata Satyanarayana Peruri 1 and Murali Musuluri 2 *

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 3049;
Date: 2011;
Original page

Keywords: Ritonavir | UV detection | recovery | precise | C18 Column.

ABSTRACT
A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of Ritonavir in tablet dosage form. Isocratic elutionat a flow rate of 1ml min -1 was employed on a symmetry C18 column at ambient temperature. The mobile phase consisted of acetonitrile: methanol 80:20(V/V).The UV detection wavelength was at 210nm. Linearity was observed in concentration range of 10-100ppm. The retention time for Ritonavir was 3.38 min. Themethod was validated as per the ICH guidelines. The proposed method can be successfully applied for the estimation of Ritonavir in pharmaceutical dosage forms.
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