Author(s): Irina Teofănescu | Elena Gologan | Gabriela Ştefănescu | Gh. Bălan
Journal: Jurnalul de Chirurgie
ISSN 1584-9341
Volume: 6;
Issue: 3;
Start page: 237;
Date: 2010;
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Keywords: HEPATOCELLULAR CARCINOMA | ALPHA-FETOPROTEIN | SQUAMOUS CELL CARCINOMA ANTIGEN | IMMUNE COMPLEXES WITH SCCA | AND IMMUNE COMPLEXES WITH AFP
ABSTRACT
Hepatocellular carcinoma is on the fifth place among malign tumours, with almost one million new cases yearly. Its incidence is raising as well its mortality. Because the only thing corelated with long term survival is its early detection all the efforts targeted the finding of the best screening and surveillance method in order to provide an early diagnosis. Hepatocellular carcinoma, having a wellknown premalign condition [liver cyrrhosis], can be early diagnosed by using biomarkers. Until now AFP, the only marker used for diagnosis, has failed mainly because its poor sensitivity. Ultrasonography is a very important tehnique for detecting early hepatocellular carcinoma but because it is operator dependent and machine dependent can give false positive results. It has been chosen to combine this method with AFP level detecting in order to early diagnose hepatocellular carcinoma. The biologic properties of new markers [SCCA, immune complexes with SCCA, AFP and immune complexes with AFP] as well as their combined use with ultrasonography bring new hope for the early diagnosis of hepatocellular carcinoma.
Journal: Jurnalul de Chirurgie
ISSN 1584-9341
Volume: 6;
Issue: 3;
Start page: 237;
Date: 2010;
VIEW PDF
DOWNLOAD PDF Original pageKeywords: HEPATOCELLULAR CARCINOMA | ALPHA-FETOPROTEIN | SQUAMOUS CELL CARCINOMA ANTIGEN | IMMUNE COMPLEXES WITH SCCA | AND IMMUNE COMPLEXES WITH AFP
ABSTRACT
Hepatocellular carcinoma is on the fifth place among malign tumours, with almost one million new cases yearly. Its incidence is raising as well its mortality. Because the only thing corelated with long term survival is its early detection all the efforts targeted the finding of the best screening and surveillance method in order to provide an early diagnosis. Hepatocellular carcinoma, having a wellknown premalign condition [liver cyrrhosis], can be early diagnosed by using biomarkers. Until now AFP, the only marker used for diagnosis, has failed mainly because its poor sensitivity. Ultrasonography is a very important tehnique for detecting early hepatocellular carcinoma but because it is operator dependent and machine dependent can give false positive results. It has been chosen to combine this method with AFP level detecting in order to early diagnose hepatocellular carcinoma. The biologic properties of new markers [SCCA, immune complexes with SCCA, AFP and immune complexes with AFP] as well as their combined use with ultrasonography bring new hope for the early diagnosis of hepatocellular carcinoma.
